Alternative Designs for Phase II Clinical Trials when Attained Sample Sizes are Different from Planned Sample Sizes
نویسندگان
چکیده
منابع مشابه
Sample sizes based on exact unconditional tests for phase II clinical trials with historical controls.
Investigated in the setting of phase II clinical trials is the two-sample binomial problem of testing H0: pe = pc H1: pe > pc, where pe and pc are the unknown target population response rates for the experimental and control groups, respectively, using the usual Z-statistic with pooled variance estimator. The cornerstones that make this paper unique are as follows. First, the emphasis is on det...
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Investigated in the setting of Phase II clinical trials is the two-sample binomial problem of testing H0 : pe = pc versus H1 : pe > pc where pe and pc are the unknown target population response rates for the experimental and control groups, respectively, using the usual Z-statistic with pooled variance estimator. The cornerstones that make this paper unique are as follows. First, the emphasis i...
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ژورنال
عنوان ژورنال: Journal of Biometrics & Biostatistics
سال: 2015
ISSN: 2155-6180
DOI: 10.4172/2155-6180.1000229